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Inhibitor of MDM2 E3 ubiquitin-protein ligase and MRP1 transporter. Inhibitor of MDM2 E3 ubiquitin-protein ligase and MRP1 transporter.
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InformationIdasanutlin (RG-7388) Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.In vitroIdasanutlin inhibits cell proliferation with IC50 of 30 nM,
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